Januvia (Sitagliptin) is an oral gliptin drug used to lower blood glucose levels amongst people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications but is not for treating type 1 diabetes.
Sitagliptin works by inhibiting the DPP-4 enzyme that destroys glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) hormones, allowing both to function more effectively. Sitagliptin increases levels of natural substances called Incretins that help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar the liver makes. and is used with a proper diet and exercise program and possibly with other medications to control high blood sugar.
Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.